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Neuroendocrine cancer with carcinoid syndrome

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The aim of this study was to analyze the clinical particularities of patients with CIU associated with AT and to evaluate the efficacy of dapsone in neuroendocrine cancer reason patients.

Subjects and Methods.

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Data regarding medical history, clinical, paraclinical findings, coexistence of AT and response to treatment were compared between patients with CU and AT and those without AT. Patients continued oral H1 antihistamines.

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Severe flares required systemic corticotherapy. Levothyroxine was administered in patients with hypothyroidism.

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Patients with CIU associated with AT had a slightly longer disease duration, a higher prevalence of angioedema Assays for thyroid autoantibodies and thyroid function should be part of the workup in patients with CU, enabling the diagnosis of autoimmune urticaria. Without correction of the underlying autoimmune mechanisms, CU may persist regardless of conventional treatment.

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Dapsone represents a therapeutic option in autoimmune CU. An optimal time for radiotherapy is within the first year after the partial surgical removal of NFMAs, particularly if a large amount of residual tumour remains.

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Patients with silent corticotroph adenoma require special attention.

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