The aim was to examine the risk of cervical neoplasia in women with SLE, overall and with respect to treatment, compared with women from the general population.
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The main outcome was defined as a first cervical neoplasia dysplasia or cancer during follow-up. Secondary outcomes were first cervical intraepithelial neoplasia CIN 1; first CIN grades 2—3; and first invasive cervical cancer during follow-up — Cox regression models estimated relative risks adjusted for age, level of education, health-care utilization, number of children, marital status, family history of cervical cancer and prior cervical screening.
The subcohort treated with other immunosuppressants was at highest risk of cervical neoplasia. SLE is a risk factor for cervical neoplasia, in particular for pre-malignant cervical lesions.
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Among patients with SLE, the risk is higher among those treated with immunosuppresants compared with those treated with antimalarials.
Keywords: systemic lupus erythematosus, cervical cancer, immunosuppressants, antimalarials, cohort study, registers, epidemiology, reproductive, DMARDS, viruses.
Rheumatology key messages Women with SLE appear to be at increased risk of cervical neoplasia. Treatment with systemic immunosupressants is a marker of higher risk among women with SLE. Introduction SLE demonstrates a marked female predominance, is hpv high risk result with numerous immunological aberrations involving both innate and adaptive immunity [ 1 ], and is typically treated with various immunomodulatory regimens.
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Several studies have suggested that an increased risk of cervical neoplasia in SLE is, at least in part, attributable to the immunosuppressive treatment [ 34 ]. Previous studies have suggested a small increase in the overall burden of cancer in SLE [ 5—7 ], but the risks for cervical pre-malignancies and invasive hpv high risk result are less well hpv high risk result. Studies to date have suggested suboptimal use of screening in women with SLE and an hpv high risk result risk of cervical dysplasia [ 89 ], but whether there is an increased risk for invasive cervical cancer remains unclear [ 510 ].
In light of the immunological aberrations associated with SLE, the immunomodulatory drugs used to treat it, and the fact that the risk of cervical neoplasia can be effectively reduced by HPV vaccination and cervical cancer screening [ 1112 ], a better understanding of these risks is of direct clinical relevance.
Hpv high risk result aim of this study was therefore to assess the incidence of pre-malignant and invasive cervical malignancies in women with SLE, and to compare these risks with those in the general paraziti kod riba. Women with SLE were considered overall and as defined by treatment exposures. Methods Study design We performed a nationwide cohort study with follow-up from January to Decemberusing population-based data from Swedish national registers on patients with SLE, cervical cancer screening and invasive cervical cancer.
Setting and data sources Swedish health care is public and tax funded. All Swedish residents are assigned a personal identification number, which allows for linkage between registers. This study was based on the Swedish Lupus Linkage cohort, which has been described in detail elsewhere [ 13 ].
Briefly, the National Patient Register NPR contains data on hospitalizations since and outpatients visits in specialized care sinceand lists main and contributory diagnoses, dates of admission and discharge, hospital and department. The Swedish Cancer Register began in and captures the mandatory reporting of incident cancers along with date, diagnosis, site of tumour, tumour stage and tumour histology.
Cervical cancer is staged according to the International Federation of Gynecology and Obstetrics classification system. During the study period, all women living in Sweden were invited to cervical screening every 3 years between ages 23 and 50 years, and every 5 years between ages 51 and 60 years.
The Cause of Death Register records the date and underlying and contributory causes of death.
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The Total Population Register hpv high risk result information on residency hpv high risk result dates of immigration or emigration for all residents in Sweden since The Multigeneration Register contains information on parents and children of those born in Sweden in hpv high risk result later and those registered in Sweden at some time since Siblings can be identified by listing all persons with the same biological parents. The date of the second SLE-coded visit served as the start of follow-up.
Drug-induced lupus ICD M Within the full SLE cohort, we identified two nested and overlapping subcohorts based on medication dispensing. The first subcohort consisted of patients treated with antimalarials who had at least one dispensing of HCQ or chloroquine phosphate. The start of follow-up was defined as the date when all inclusion criteria were fulfilled i.
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Any dispensing for immunosuppressant medications listed below resulted in exclusion if prior to the start of follow-up, and censoring and subsequent switching of subcohorts if following the start of antimalarial therapy. The start of follow-up was defined as the date when all of the SLE diagnoses and date of first immunosuppressant dispensing criteria were fulfilled. Person-time in this subcohort was classified as once exposed, always exposed. Through Statistics Sweden, comparator subjects from the general population were identified and matched to each individual with SLEon sex, year of birth and county of residence.
Matching was not preserved after applying further exclusion criteria, but matching factors were accounted for in the analyses. The start of follow-up was set as the same date as their respective index individual with SLE.
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Women who had undergone a total hysterectomy or had solid organ transplantation prior to or during follow-up were excluded or censored, respectively. Women with a history of invasive cervical cancer were also excluded. Women could not contribute person-time to the study until they turned 23 years old, at which point they were eligible for the national screening programme.
The composite primary outcome was split into three secondary outcomes and analysed separately.
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The first secondary outcome was a first ever histopathological diagnosis of CIN 1, in women with no history of cervical dysplasia. The third secondary outcome was a first ever diagnosis of invasive cervical cancer. Number of biological children identified in the multigeneration register served as a marker of parity three categories: 0, 1—2, 3 or more.
Use of oral steroids at the start of follow-up was determined by recorded use in the PDR within 3 months before the start of follow-up, and use of oral contraceptives OCs by recorded use within 6 months before the start of follow-up. Statistical analysis We assessed the total number of events, person-years at risk and estimated incidence rates of each outcome in each cohort.